When working with Clarithromycin, a macrolide antibiotic used to treat a wide range of bacterial infections. Also known as Biaxin, it blocks bacterial protein synthesis by binding to the 50S ribosomal subunit, halting growth of susceptible microbes.
This medication belongs to the macrolide class, a group that includes azithromycin and erythromycin and shares a similar mechanism of action. The class is prized for its good tissue penetration, making it effective against respiratory bacterial infections, such as community‑acquired pneumonia, bronchitis, and sinusitis. Because it concentrates in lung tissue, clarithromycin often tops treatment charts for Helicobacter pylori eradication, where it works alongside acid‑suppressing drugs to clear the stomach lining.
Understanding dosage is crucial: adults typically take 250‑500 mg every 12 hours for 7‑14 days, while children’s doses are weight‑based. Adjustments are needed for liver impairment, as the drug is metabolized hepatically, and for patients on certain CYP3A4 inhibitors, which can raise clarithromycin levels and increase the risk of QT‑prolongation. Speaking of risks, common side effects include gastrointestinal upset, taste disturbances, and mild liver enzyme changes; serious concerns involve arrhythmias and severe allergic reactions. Drug‑interaction checks are a must because clarithromycin can boost levels of statins, warfarin, and some anti‑seizure meds, sometimes requiring dose reductions or alternative therapies.
Below you’ll find a curated set of articles that dive deeper into each of these areas—clinical uses, safety considerations, and practical tips for getting the most out of clarithromycin while minimizing pitfalls. Whether you’re a patient looking for clear guidance or a health‑care professional needing a quick refresher, the posts ahead cover the full spectrum of what you need to know.
