When your dog is in pain from arthritis or cancer, piroxicam, a nonsteroidal anti-inflammatory drug (NSAID) prescribed for dogs to reduce pain and inflammation. Also known as Feldene, it's one of the strongest painkillers vets use for dogs with chronic conditions. But it’s not a casual choice—this drug demands caution. Unlike human NSAIDs like ibuprofen, which can be deadly to dogs, piroxicam is FDA-approved for veterinary use, but only under strict supervision. It works by blocking enzymes that cause swelling and pain, making it effective for osteoarthritis and even certain types of tumors like bladder cancer.
What makes piroxicam different from other dog pain meds? It’s long-lasting. One dose can last 24 to 48 hours, which is convenient—but also risky. If your dog has kidney disease, liver issues, or a history of stomach ulcers, piroxicam can make things worse. Studies show that up to 20% of dogs on long-term piroxicam develop gastrointestinal bleeding or kidney damage. That’s why vets always run blood tests before starting it and check again after a few weeks. It’s also not safe to combine with steroids or other NSAIDs like carprofen or meloxicam. Even a single extra dose can be dangerous. Some owners try to save money by buying it online without a prescription, but that’s a gamble with your dog’s life. Legitimate vet clinics require a prescription for a reason.
There are safer alternatives if your dog can’t handle piroxicam. meloxicam, a gentler NSAID commonly used for dog arthritis is often the first choice. For cancer-related pain, tramadol, an opioid-like pain reliever with fewer organ risks might be added. And for long-term joint support, supplements like glucosamine or CBD oil are gaining traction as part of a multi-pronged plan. But if your vet recommends piroxicam, it’s usually because the benefits outweigh the risks—for example, when a tumor is causing severe discomfort and other options have failed.
Watch for warning signs: vomiting, black tarry stools, loss of appetite, increased thirst or urination, or lethargy. These aren’t normal side effects—they’re red flags. Keep a log of your dog’s behavior and appetite, and call your vet immediately if anything changes. Never stop or restart piroxicam without consulting your vet, even if your dog seems better. The drug stays in the system longer than you think, and sudden changes can trigger complications.
Below, you’ll find real-world advice from pet owners and vets on managing pain in dogs with piroxicam, spotting hidden dangers, and choosing the right path when the risks are high. Whether you’re considering this drug for the first time or already using it, these posts will help you make smarter, safer decisions.
